Expressive

rs10265814 - EPHA1-AS1

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide meta-analysis, fine-mapping, and integrative prioritization implicate new Alzheimer's disease risk genes - Unknown journal (n.d.) · Unknown authors · PubMed 33589840

    ABSTRACT: Genome-wide association studies (GWAS) have discovered numerous genomic loci associated with Alzheimer's disease (AD), yet the causal genes and variants remain incompletely identified. We performed an updated genome-wide AD meta-analysis, which identified 37 risk loci, including novel associations near CCDC6, TSPAN14, NCK2, and SPRED2. Using three SNP-level fine-mapping methods, we identified 21 SNPs with greater than 50% probability each of being causally involved in AD risk, and others strongly suggested by functional annotation. We followed this with colocalization analyses across 109 gene expression quantitative trait loci (eQTL) datasets, and prioritization of genes using protein interaction networks and tissue-specific expression. Combining this information into a quantit

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Mediterranean-style diet Moderate

    Plant-based diets rich in polyphenols and antioxidants reduce neuroinflammation and amyloid accumulation in the brain.

    Emphasize vegetables, fruits, whole grains, legumes, fish, and olive oil; limit processed foods and red meat

Exercise

  • aerobic exercise Moderate

    Aerobic exercise improves cerebrovascular function and reduces neuroinflammation, supporting brain health against neurodegenerative pathology.

    150 minutes per week of moderate-intensity aerobic activity

Lifestyle

  • cognitive engagement and mental stimulation Moderate

    Cognitive reserve from lifelong learning and mental engagement provides a buffer against age-related cognitive decline.

    Daily mental challenges: learning new skills, puzzles, reading, or educational pursuits

  • sleep quality and quantity Moderate

    Sleep enables glymphatic clearance of amyloid-beta and tau protein; insufficient sleep increases neurodegeneration risk.

    Target 7-9 hours nightly; consistent sleep schedule; screen for and treat sleep apnea if present

  • social engagement and community connection Moderate

    Social interaction provides cognitive and emotional stimulation that helps maintain neural function and reduces neuroinflammation.

    Regular social activities: clubs, groups, family time, or volunteer work at least weekly

Screening

  • baseline cognitive screening and monitoring Moderate

    Establishing cognitive baseline in mid-life allows detection of early decline and enables timely intervention.

    Baseline cognitive assessment at age 50-55; annual re-assessment if family history of Alzheimer's disease present

  • blood pressure and cardiovascular health Moderate

    Hypertension damages cerebral microvasculature and accelerates amyloid pathology independent of genetic risk factors.

    Regular BP monitoring; maintain systolic pressure <130 mmHg; manage other cardiovascular risk factors