rs10264081 - COL26A1
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-Wide Association Analysis of Single-Breath Dl . - American journal of respiratory cell and molecular biology (2019) · Sakornsakolpat P, McCormack M, Bakke P, Gulsvik A, Make BJ, Crapo JD, Cho MH, Silverman EK · PubMed 30694715
Dl is a widely used pulmonary function test in clinical practice and a particularly useful measure for assessing patients with chronic obstructive pulmonary disease (COPD). We hypothesized that elucidating genetic determinants of Dl could lead to better understanding of the genetic architecture of COPD. We estimated the heritability of Dl using common genetic variants and performed genome-wide association analyses in four cohorts enriched for subjects with COPD (COPDGene [Genetic Epidemiology of COPD], NETT [National Emphysema Treatment Trial], GenKOLS [Genetics of Chronic Obstructive Lung Disease study], and TESRA [Treatment of Emphysema With a Gamma-Selective Retinoid Agonist study]) using a combined European ancestry white dataset and a COPDGene African American dataset. We assessed our
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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pulmonary function testing including DLCO measurement Moderate
COL26A1 T allele associated with reduced diffusion capacity of carbon monoxide in large GWAS; baseline assessment helps stratify respiratory risk.
order spirometry with DLCO testing if not recently done