rs10263935 - KCTD7

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study - Unknown journal (n.d.) · Unknown authors · PubMed 21223598

  ABSTRACT: Background Aortic root diameter is a clinically relevant trait due to its known relationship with the pathogenesis of aortic regurgitation and risk for aortic dissection. African Americans are an understudied population despite a particularly high burden of cardiovascular diseases. We report a genome-wide association study on aortic root diameter among African Americans enrolled in the HyperGEN study. We invoked a two-stage, mixed model procedure to jointly identify SNP allele and copy number variation effects. Results Results suggest novel genetic contributors along a large region between the CRCP and KCTD7 genes on chromosome 7 (p = 4.26 × 10-7); and the SIRPA and PDYN genes on chromosome 20 (p = 3.28 × 10-8). Conclusions The regions we discovered are candidates for future st

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