rs10263639 - STAG3L4 - MTATP6P21

Magnitude 2.0 · 1 study on file

Reported associations

• A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study - Unknown journal (n.d.) · Unknown authors · PubMed 17903305

  ABSTRACT: Background Breast and prostate cancer are two commonly diagnosed cancers in the United States. Prior work suggests that cancer causing genes and cancer susceptibility genes can be identified. Methods We conducted a genome-wide association study (Affymetrix 100K SNP GeneChip) of cancer in the community-based Framingham Heart Study. We report on 2 cancer traits - prostate cancer and breast cancer - in up to 1335 participants from 330 families (54% women, mean entry age 33 years). Multivariable-adjusted residuals, computed using Cox proportional hazards models, were tested for association with qualifying SNPs (70, 987 autosomal SNPs with genotypic call rate ≥80%, minor allele frequency ≥10%, Hardy-Weinberg test p ≥ 0.001) using generalized estimating equations (GEE) models

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