rs10262566 - DPY19L2P1

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide association analyses of posttraumatic stress disorder and its symptom subdomains in the Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 33510476

  ABSTRACT: We conducted genome-wide association analyses in over 250,000 participants of European and African ancestry from the Million Veteran Program using electronic health record-validated posttraumatic stress disorder (PTSD) diagnosis and quantitative symptom phenotypes. Applying genome-wide multiple testing correction, we identified three significant loci in European case-control analyses and 15 loci in quantitative symptom analyses. Genomic structural equation modeling indicated tight coherence of a PTSD symptom factor that shares genetic variance with a distinct internalizing (mood-anxiety-neuroticism) factor. Partitioned heritability indicated enrichment in several cortical and subcortical regions, and imputed genetically regulated gene expression in these regions was used to ident

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