Expressive

rs10258415 - CYTH3 - FAM220A

Magnitude 4.5 · 2 studies on file

Reported associations

  • A genome-wide association study of plasma concentrations of warfarin enantiomers and metabolites in sub-Saharan black-African patients - Unknown journal (n.d.) · Unknown authors · PubMed 36210801

    ABSTRACT: Diversity in pharmacogenomic studies is poor, especially in relation to the inclusion of black African patients. Lack of funding and difficulties in recruitment, together with the requirement for large sample sizes because of the extensive genetic diversity in Africa, are amongst the factors which have hampered pharmacogenomic studies in Africa. Warfarin is widely used in sub-Saharan Africa, but as in other populations, dosing is highly variable due to genetic and non-genetic factors. In order to identify genetic factors determining warfarin response variability, we have conducted a genome-wide association study (GWAS) of plasma concentrations of warfarin enantiomers/metabolites in sub-Saharan black-Africans. This overcomes the issue of non-adherence and may have greater sensitiv

  • Genome-wide metabolite quantitative trait loci analysis (mQTL) in red blood cells from volunteer blood donors - Unknown journal (n.d.) · Unknown authors · PubMed 36395887

    ABSTRACT: The red blood cell (RBC)-Omics study, part of the larger NHLBI-funded Recipient Epidemiology and Donor Evaluation Study (REDS-III), aims to understand the genetic contribution to blood donor RBC characteristics. Previous work identified donor demographic, behavioral, genetic, and metabolic underpinnings to blood donation, storage, and (to a lesser extent) transfusion outcomes, but none have yet linked the genetic and metabolic bodies of work. We performed a genome-wide association (GWA) analysis using RBC-Omics study participants with generated untargeted metabolomics data to identify metabolite quantitative trait loci in RBCs. We performed GWA analyses of 382 metabolites in 243 individuals imputed using the 1000 Genomes Project phase 3 all-ancestry reference panel. Analyses were

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Drug interactions

  • warfarin dosing with your doctor or pharmacist Moderate

    This variant affects warfarin metabolism through altered S-6-hydroxywarfarin metabolite levels, which may impact drug efficacy and safety.

    Inform your healthcare provider about this variant if prescribed warfarin; dosing adjustment may be needed.