rs10258381 - CPAMD8P1 - U3

Magnitude 2.2 · 1 study on file

Reported associations

• Genome‐wide search for genes affecting the age at diagnosis of type 1 diabetes - Unknown journal (n.d.) · Unknown authors · PubMed 33179336

  ABSTRACT: Abstract Background Type 1 diabetes (T1D) is an autoimmune disease affecting individuals in the early years of life. Although previous studies have identified genetic loci influencing T1D diagnosis age, these studies did not investigate the genome with high resolution. Objective and methods We performed a genome‐wide meta‐analysis for age at diagnosis with cohorts from Finland (Finnish Diabetic Nephropathy Study), the United Kingdom (UK Genetic Resource Investigating Diabetes) and Sardinia. Through SNP associations, transcriptome‐wide association analysis linked T1D diagnosis age and gene expression. Results We identified two chromosomal regions associated with T1D diagnosis age: multiple independent variants in the HLA region on chromosome 6 and a locus on chromosome 17q12

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