rs10255299 - DOCK4

Magnitude 2.2 · 1 study on file

Reported associations

• Genetic associations with C-reactive protein level and white blood cell count in the KARE study. - International journal of immunogenetics (2013) · Kong M, Lee C · PubMed 22788528

  C-reactive protein (CRP) and white blood cell (WBC) have been utilized as critical markers contributing to acute and chronic inflammation. Genome-wide associations were examined to identify nucleotide sequence variants associated with the two markers using 8842 individuals in the Korean Association REsource (KARE) study. A total of six and three nucleotide variants turned out to be associated with CRP and WBC (P < 1.42 × 10(-7) ), and they were mutually exclusive. The only common variant associated with CRP was rs2393791 within hepatocyte nuclear factor 1 alpha (HNF1A) gene [minor allele frequency (MAF) = 0.478]. The only common variant associated with WBC [MAF = 0.468] was rs8078723, an intergenic single nucleotide polymorphism located between proteasome 26S subunits non-ATPase 3

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