Expressive

rs10255295 - RCC2P3 - Y_RNA

Magnitude 2.2 · 2 studies on file

Reported associations

  • Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis - Unknown journal (n.d.) · Unknown authors · PubMed 23453885

    ABSTRACT: Summary Background Findings from family and twin studies suggest that genetic contributions to psychiatric disorders do not in all cases map to present diagnostic categories. We aimed to identify specific variants underlying genetic effects shared between the five disorders in the Psychiatric Genomics Consortium: autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia. Methods We analysed genome-wide single-nucleotide polymorphism (SNP) data for the five disorders in 33 332 cases and 27 888 controls of European ancestory. To characterise allelic effects on each disorder, we applied a multinomial logistic regression procedure with model selection to identify the best-fitting model of relations between genot

  • Genome-wide association of mood-incongruent psychotic bipolar disorder - Unknown journal (n.d.) · Unknown authors · PubMed 23092984

    ABSTRACT: Mood-incongruent psychotic features (MICP) are familial symptoms of bipolar disorder (BP) that also occur in schizophrenia (SZ), and may represent manifestations of shared etiology between the major psychoses. In this study we have analyzed three large samples of BP with imputed genome-wide association data and have performed a meta-analysis of 2196 cases with MICP and 8148 controls. We found several regions with suggestive evidence of association (P<10-6), although no marker met genome-wide significance criteria. The top associations were on chromosomes: 6q14.2 within the PRSS35/SNAP91 gene complex (rs1171113, P=9.67 × 10-8); 3p22.2 downstream of TRANK/LBA1 (rs9834970, P=9.71 × 10-8); and 14q24.2 in an intron of NUMB (rs2333194, P=7.03 × 10-7). These associations were

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