Expressive

rs10254670 - DNAJB9 - LINC02903

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways. - Nature genetics (2022) · Watanabe K, Jansen PR, Savage JE, Nandakumar P, Wang X, Hinds DA, Gelernter J, Levey DF, Polimanti R, Stein MB, Van Someren EJW, Smit AB, Posthuma D · PubMed 35835914

    Insomnia is a heritable, highly prevalent sleep disorder for which no sufficient treatment currently exists. Previous genome-wide association studies with up to 1.3 million subjects identified over 200 associated loci. This extreme polygenicity suggested that many more loci remain to be discovered. The current study almost doubled the sample size to 593,724 cases and 1,771,286 controls, thereby increasing statistical power, and identified 554 risk loci (including 364 novel loci). To capitalize on this large number of loci, we propose a novel strategy to prioritize genes using external biological resources and functional interactions between genes across risk loci. Of all 3,898 genes naively implicated from the risk loci, we prioritize 289 and find brain-tissue expression spec

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • genetic insomnia predisposition and preventive strategies High

    Variant at rs10254670 independently associated with insomnia in 2.36 million-person GWAS; clinical risk stratification may guide screening and early intervention

    discuss genetic findings with healthcare provider to explore personalized sleep assessment and preventive approaches

Screening

  • insomnia symptoms and sleep quality High

    Genetic predisposition at rs10254670 increases insomnia risk; regular monitoring enables early detection and intervention

    assess sleep onset latency, night awakenings, daytime impairment, and sleep quality monthly or as symptoms emerge