rs10252923 - FZD1 - LINC02932

Magnitude 4.5 · 1 study on file

Reported associations

• Wnt receptor gene was associated with schizophrenia in genome-wide SNP analysis of the Australian Schizophrenia Research Bank cohort. - The Australian and New Zealand journal of psychiatry (2021) · Liu X, Low SK, Atkins JR, Wu JQ, Reay WR, Cairns HM, Green MJ, Schall U, Jablensky A, Mowry B, Michie PT, Catts SV, Henskens F, Pantelis C, Loughland C, Boddy AV, Tooney PA, Scott RJ, Carr VJ, Cairns MJ · PubMed 31735061

  Large-scale genetic analysis of common variation in schizophrenia has been a powerful approach to understanding this complex but highly heritable psychotic disorder. To further investigate loci, genes and pathways associated more specifically in the well-characterized Australian Schizophrenia Research Bank cohort, we applied genome-wide single-nucleotide polymorphism analysis in these three annotation categories. We performed a case-control genome-wide association study in 429 schizophrenia samples and 255 controls. Post-genome-wide association study analyses were then integrated with genomic annotations to explore the enrichment of variation at the gene and pathway level. We also examine candidate single-nucleotide polymorphisms with potential function within expression quantitative trait

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