rs10250565 - MTHFD2P5 - PCLO
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland - Unknown journal (n.d.) · Unknown authors · PubMed 30718454
ABSTRACT: Stress is associated with poorer physical and mental health. To improve our understanding of this link, we performed genome-wide association studies (GWAS) of depressive symptoms and genome-wide by environment interaction studies (GWEIS) of depressive symptoms and stressful life events (SLE) in two UK population-based cohorts (Generation Scotland and UK Biobank). No SNP was individually significant in either GWAS, but gene-based tests identified six genes associated with depressive symptoms in UK Biobank (DCC, ACSS3, DRD2, STAG1, FOXP2 and KYNU; p < 2.77 × 10−6). Two SNPs with genome-wide significant GxE effects were identified by GWEIS in Generation Scotland: rs12789145 (53-kb downstream PIWIL4; p = 4.95 × 10−9; total SLE) and rs17070072 (intronic to ZCCHC2
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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stress management practices Moderate
Variant shows gene-environment interaction where stressful life events amplify depressive symptom risk
Implement regular stress reduction techniques; consider therapeutic support if available
Screening
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depression screening Moderate
The A allele at rs10250565 is associated with increased depressive symptoms particularly in response to independent stressful life events
Periodic screening for depressive symptoms; increased frequency during stressful periods