Expressive

rs10250 - MAP2K2

Magnitude 2.0 · 2 studies on file

Reported associations

  • Shared Genetic and Experimental Links between Obesity-Related Traits and Asthma Subtypes in UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 31669095

    ABSTRACT: Background: Clinical and epidemiological studies have shown that obesity is associated with asthma and that these associations differ by asthma subtypes. Little is known about the shared genetic components between obesity and asthma. Objective: To identify shared genetic associations between obesity-related traits and asthma subtypes in adults. Methods: A cross-trait genome-wide association study (GWAS) was performed using 457,822 individuals of European ancestry from the UK Biobank. Experimental evidence to support the role of genes significantly associated with both obesity-related traits and asthma via GWAS was sought using results from obese vs. lean mouse RNA-seq and RT-PCR experiments. Results: We found a substantial positive genetic correlation between BMI and later-onset

  • Identification of Functional Genetic Determinants of Cardiac Troponin T and I in a Multi-Ethnic Population and Causal Associations with Atrial Fibrillation - Unknown journal (n.d.) · Unknown authors · PubMed 34732054

    ABSTRACT: Background Elevated cardiac troponin levels in blood are associated with increased risk of cardiovascular diseases (CVDs) and mortality. Cardiac troponin levels are heritable, but their genetic architecture remains elusive. Methods We conducted a trans-ethnic genome-wide association analysis on high-sensitivity cardiac troponin T and I levels (hs-cTnT and hs-cTnI) in 24,617 and 14,336 participants free of coronary heart disease and heart failure from six population-based cohorts, followed by a series of bioinformatic analyses to decipher the genetic architecture of hs-cTnT and hs-cTnI. Results We identified four genome-wide significant loci for hs-cTnT including a novel locus, rs3737882 in PPFIA4, and three previously reported loci at NCOA2, TRAM1 and BCL2. One known locus at VCL

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.