rs10245124 - NXPH1
Magnitude 2.2 · 1 study on file
Reported associations
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Novel Genetic Loci Identified for the Pathophysiology of Childhood Obesity in the Hispanic Population - Unknown journal (n.d.) · Unknown authors · PubMed 23251661
ABSTRACT: Genetic variants responsible for susceptibility to obesity and its comorbidities among Hispanic children have not been identified. The VIVA LA FAMILIA Study was designed to genetically map childhood obesity and associated biological processes in the Hispanic population. A genome-wide association study (GWAS) entailed genotyping 1.1 million single nucleotide polymorphisms (SNPs) using the Illumina Infinium technology in 815 children. Measured genotype analysis was performed between genetic markers and obesity-related traits i.e., anthropometry, body composition, growth, metabolites, hormones, inflammation, diet, energy expenditure, substrate utilization and physical activity. Identified genome-wide significant loci: 1) corroborated genes implicated in other studies (MTNR1B, ZNF259
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Genetic predisposition to obesity and preventive strategy Moderate
Carrying G allele associated with increased obesity risk; medical guidance can optimize prevention approach.
Screening
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Body weight and obesity-related measurements Moderate
rs10245124 G allele shows association with obesity-related traits in GWAS; close monitoring appropriate for carriers.
Track weight and BMI at least quarterly; consider annual obesity risk assessment.