Expressive

rs10244093 - MAGI2

Magnitude 2.2 · 1 study on file

Reported associations

  • Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration - Unknown journal (n.d.) · Unknown authors · PubMed 31719535

    ABSTRACT: Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interactions in joint analyses, we identify 49 previously unreported lipid loci, and 10 additional previously unreported lipid loci in a restricted sample of European-ancestry cohorts. In addition, we identify new gene-sleep interactions for known lipid loci such as LPL and PCSK9. The previously unreported lip

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • LDL cholesterol concentration Moderate

    MAGI2 variants interact with short sleep to increase LDL cholesterol; monitoring identifies rising risk

    Annual lipid panel including LDL; discuss trends with healthcare provider if levels rising

    • GWAS_CATALOG:31719535

Discuss with your doctor

  • MAGI2 sleep-lipid interaction risk management Moderate

    MAGI2 shows environment-specific effects on LDL; clinician can tailor approach based on sleep patterns and lipid profile

    Discuss sleep optimization vs. statin therapy based on your sleep habits and lipid levels

    • GWAS_CATALOG:31719535

Lifestyle

  • Prioritize consistent adequate sleep 7-9 hours Moderate

    MAGI2 risk variants associated with elevated LDL in short sleepers; adequate sleep may mitigate genetic risk

    Target 7-9 hours consistent nightly sleep; track patterns if regularly sleeping under 6 hours

    • GWAS_CATALOG:31719535