rs10243591 - PGBD4P1 - TRBV29-1
Magnitude 2.8 · 1 study on file
Reported associations
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Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis - Unknown journal (n.d.) · Unknown authors · PubMed 28754779
ABSTRACT: Objective Alcohol-related pancreatitis is associated with a disproportionately large number of hospitalisations among GI disorders. Despite its clinical importance, genetic susceptibility to alcoholic chronic pancreatitis (CP) is poorly characterised. To identify risk genes for alcoholic CP and to evaluate their relevance in non-alcoholic CP, we performed a genome-wide association study and functional characterisation of a new pancreatitis locus. Design 1959 European alcoholic CP patients and population-based controls from the KORA, LIFE and INCIPE studies (n=4708) as well as chronic alcoholics from the GESGA consortium (n=1332) were screened with Illumina technology. For replication, three European cohorts comprising 1650 patients with non-alcoholic CP and 6695 controls originat
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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regular alcohol consumption Moderate
rs10243591 is associated with increased risk of alcoholic chronic pancreatitis, likely through T-cell receptor mediated immune response to alcohol-induced pancreatic injury
Limit or avoid alcohol intake; discuss safe consumption limits with healthcare provider
Screening
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baseline pancreatic function assessment Moderate
Genetic predisposition to alcoholic chronic pancreatitis suggests early establishment of baseline pancreatic markers for future comparison and monitoring
Discuss with healthcare provider about lipase, amylase levels and appropriate imaging baseline