Expressive

rs10242223 - SDK1

Magnitude 2.2 · 1 study on file

Reported associations

  • Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases - Unknown journal (n.d.) · Unknown authors · PubMed 31527586

    ABSTRACT: Gastroesophageal reflux disease (GERD) is caused by gastric acid entering the esophagus. GERD has high prevalence and is the major risk factor for Barrett's esophagus (BE) and esophageal adenocarcinoma (EA). We conduct a large GERD GWAS meta-analysis (80,265 cases, 305,011 controls), identifying 25 independent genome-wide significant loci for GERD. Several of the implicated genes are existing or putative drug targets. Loci discovery is greatest with a broad GERD definition (including cases defined by self-report or medication data). Further, 91% of the GERD risk-increasing alleles also increase BE and/or EA risk, greatly expanding gene discovery for these traits. Our results map genes for GERD and related traits and uncover potential new drug targets for these conditions. Gastr

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • GERD risk and personalized prevention strategies Moderate

    rs10242223-A increases GERD risk (OR=1.04, p=2.54e-8), a condition affecting approximately 20% of the population with significant disease burden.

Screening

  • Barrett's esophagus screening eligibility Moderate

    rs10242223-A increases esophageal adenocarcinoma and Barrett's esophagus risk (p=0.0040), which are precancerous conditions requiring surveillance.