Expressive

rs10240058 - TWIST1

Magnitude 2.2 · 2 studies on file

Reported associations

  • The Genetic Architecture of Depression in Individuals of East Asian Ancestry - Unknown journal (n.d.) · Unknown authors · PubMed 34586374

    ABSTRACT: Key Points Question Are the genetic risk factors for depression the same in individuals of East Asian and European descent? Findings In this genome-wide association meta-analysis of depression in 194 548 individuals with East Asian ancestry, 2 novel genetic associations were identified, one of which is specific to individuals of East Asian descent living in East Asian countries. There was limited evidence for transferability with only 11% of depression loci previously identified in individuals of European descent reaching nominal significance levels in the individuals of East Asian descent. Meaning Caution is advised against generalizing findings about genetic risk factors for depression beyond the studied population. This genetic association study investigates the genetics of

  • A genome-wide association study of mass spectrometry proteomics using a nanoparticle enrichment platform - Unknown journal (n.d.) · Unknown authors · PubMed 41310232

    ABSTRACT: Most studies to date of protein quantitative trait loci (pQTLs) have relied on affinity proteomics platforms, which provide only limited information about the targeted protein isoforms and may be affected by genetic variation in their epitope binding. Here we show that mass spectrometry (MS)-based proteomics can complement these studies and provide insights into the role of specific protein isoform and epitope-altering variants. Using the Seer Proteograph nanoparticle enrichment MS platform, we identified and replicated new pQTLs in a genome-wide association study of proteins in blood plasma samples from two cohorts and evaluated previously reported pQTLs from affinity proteomics platforms. We found that >30% of the evaluated pQTLs were confirmed by MS proteomics to be consistent

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