rs10239506 - PDE1C

Magnitude 2.0 · 1 study on file

Reported associations

• Gout and type 2 diabetes have a mutual inter-dependent effect on genetic risk factors and higher incidences. - Rheumatology (Oxford, England) (2012) · Lai HM, Chen CJ, Su BY, Chen YC, Yu SF, Yen JH, Hsieh MC, Cheng TT, Chang SJ · PubMed 22179738

  To explore the causal relationship between gout and Type 2 diabetes based on genetic evidence and national outpatient database. Twenty male gout patients with early-onset, gout family history, without a habit of alcohol consumption or obesity before the first attack of gout were selected from hospital in 2010; and 42 unrelated male Chinese subjects were selected from HapMap as controls for genome-wide analysis study (GWAS). The comorbid diseases with gout were revealed by applying the significant single nucleotide polymorphisms (SNPs) to MetaCore platform, and the comorbid relationship was analysed by standardized incidence ratio (SIR) from outpatient database. A total of 334 SNPs were significantly related to gout in GWAS (P < 10(-7)), and Type 2 diabetes was the most significantly as

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