rs10238953 - SEM1

Magnitude 2.0 · 1 study on file

Reported associations

• Genome-wide mapping of global-to-local genetic effects on human facial shape - Unknown journal (n.d.) · Unknown authors · PubMed 29459680

  ABSTRACT: Genome-wide association scans of complex multipartite traits like the human face typically use preselected phenotypic measures. Here we report a data-driven approach to phenotyping facial shape at multiple levels of organization, allowing for an open-ended description of facial variation, while preserving statistical power. In a sample of 2,329 persons of European ancestry we identified 38 loci, 15 of which replicated in an independent European sample (n=1,719). Four loci were completely novel. For the others, additional support (n=9) or pleiotropic effects (n=2) were found in the literature, but the results reported here were further refined. All 15 replicated loci revealed distinctive patterns of global-to-local genetic effects on facial shape and showed enrichment for active c

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