rs1023674 - CSPG4BP - ESM1

Magnitude 2.0 · 1 study on file

Reported associations

• Bivariate genome-wide association study (GWAS) of body mass index and blood pressure phenotypes in northern Chinese twins - PloS one (2021) · Li Z, Wang W, Tian X, Duan H, Xu C, Zhang D · PubMed 33539483

  ABSTRACT: Recently, new loci related to body mass index (BMI) or blood pressure (BP) have been identified respectively in genome-wide association studies (GWAS). However, limited studies focused on jointly associated genetic variance between systolic pressure (SBP), diastolic pressure (DBP) and BMI. Therefore, a bivariate twin study was performed to explore the genetic variants associated with BMI-SBP, BMI-DBP and SBP-DBP. A total of 380 twin pairs (137 dizygotic pairs and 243 monozygotic pairs) recruited from Qingdao Twin Registry system were used to access the genetic correlations (0.2108 for BMI-SBP, 0.2345 for BMI-DBP, and 0.6942 for SBP-DBP, respectively) by bivariate Cholesky decomposition model. Bivariate GWAS in 137 dizygotic pairs nominated 27 single identified 27 quantitative tra

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