rs10235034 - CYTH3 - FAM220A
Magnitude 2.2 · 1 study on file
Reported associations
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A genome‐wide association meta‐analysis of all‐cause and vascular dementia - Unknown journal (n.d.) · Unknown authors · PubMed 39046104
ABSTRACT: Abstract INTRODUCTION Dementia is a multifactorial disease with Alzheimer's disease (AD) and vascular dementia (VaD) pathologies making the largest contributions. Yet, most genome‐wide association studies (GWAS) focus on AD. METHODS We conducted a GWAS of all‐cause dementia (ACD) and examined the genetic overlap with VaD. Our dataset includes 800,597 individuals, with 46,902 and 8702 cases of ACD and VaD, respectively. Known AD loci for ACD and VaD were replicated. Bioinformatic analyses prioritized genes that are likely functionally relevant and shared with closely related traits and risk factors. RESULTS For ACD, novel loci identified were associated with energy transport (SEMA4D), neuronal excitability (ANO3), amyloid deposition in the brain (RBFOX1), and magnetic resonanc
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Dementia risk profile and prevention strategy Moderate
CYTH3-FAM220A variants influence dementia susceptibility; early risk identification enables targeted prevention
Schedule visit with primary care or neurology to discuss genetic risk and evidence-based prevention options
Screening
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Cognitive and neurological assessment for dementia risk Moderate
rs10235034 T allele associated with dementia risk in large GWAS (p=4.00e-7, n=524,852)
Discuss baseline cognitive assessment with primary care; establish monitoring schedule