rs10234366 - HMGN1P19 - EPS15P1

Magnitude 2.2 · 1 study on file

Reported associations

• Use of genetic variation to separate the effects of early and later life adiposity on disease risk: mendelian randomisation study - Unknown journal (n.d.) · Unknown authors · PubMed 32376654

  ABSTRACT: Abstract Objective To evaluate whether body size in early life has an independent effect on risk of disease in later life or whether its influence is mediated by body size in adulthood. Design Two sample univariable and multivariable mendelian randomisation. Setting The UK Biobank prospective cohort study and four large scale genome-wide association studies (GWAS) consortiums. Participants 453 169 participants enrolled in UK Biobank and a combined total of more than 700 000 people from different GWAS consortiums. Exposures Measured body mass index during adulthood (mean age 56.5) and self-reported perceived body size at age 10. Main outcome measures Coronary artery disease, type 2 diabetes, breast cancer, and prostate cancer. Results Having a larger genetically predicted body

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