Expressive

rs10232743 - URGCP-MRPS24

Magnitude 2.2 · 2 studies on file

Reported associations

  • Genetic drivers of heterogeneity in type 2 diabetes pathophysiology - Unknown journal (n.d.) · Unknown authors · PubMed 38374256

    ABSTRACT: Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes and molecular mechanisms that are often specific to cell type. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (P < 5 × 10−8) that map to 611 loci, of which 145 loci are, to our knowledge, previously unreported. We define eight non-overlapping clusters of T2D signals that are characterized by distinct profiles of cardiometabolic trait associations. These clusters are differentially enriched for cell-type-sp

  • Novel Genetic Loci Identified for the Pathophysiology of Childhood Obesity in the Hispanic Population - Unknown journal (n.d.) · Unknown authors · PubMed 23251661

    ABSTRACT: Genetic variants responsible for susceptibility to obesity and its comorbidities among Hispanic children have not been identified. The VIVA LA FAMILIA Study was designed to genetically map childhood obesity and associated biological processes in the Hispanic population. A genome-wide association study (GWAS) entailed genotyping 1.1 million single nucleotide polymorphisms (SNPs) using the Illumina Infinium technology in 815 children. Measured genotype analysis was performed between genetic markers and obesity-related traits i.e., anthropometry, body composition, growth, metabolites, hormones, inflammation, diet, energy expenditure, substrate utilization and physical activity. Identified genome-wide significant loci: 1) corroborated genes implicated in other studies (MTNR1B, ZNF259

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Refined carbohydrates and added sugars Moderate

    High glycemic foods increase insulin demand; T-allele carriers have increased T2D susceptibility

    Limit refined grains, sugary drinks; prefer whole grains and legumes

Exercise

  • Regular aerobic and resistance exercise Moderate

    Exercise improves insulin sensitivity and glucose metabolism, offsetting genetic T2D risk

    150 min/week moderate aerobic activity plus 2x weekly resistance training

Screening

  • Type 2 diabetes screening Moderate

    rs10232743 T-allele increases type 2 diabetes risk in large GWAS cohort (n=2.5M, p=3e-8)

    Fasting glucose and HbA1c every 1-2 years