rs10230862 - ELFN1 - MAD1L1

Magnitude 2.2 · 1 study on file

Reported associations

• Genetic, parental and lifestyle factors influence telomere length - Unknown journal (n.d.) · Unknown authors · PubMed 35681050

  ABSTRACT: The average length of telomere repeats (TL) declines with age and is considered to be a marker of biological ageing. Here, we measured TL in six blood cell types from 1046 individuals using the clinically validated Flow-FISH method. We identified remarkable cell-type-specific variations in TL. Host genetics, environmental, parental and intrinsic factors such as sex, parental age, and smoking are associated to variations in TL. By analysing the genome-wide methylation patterns, we identified that the association of maternal, but not paternal, age to TL is mediated by epigenetics. Single-cell RNA-sequencing data for 62 participants revealed differential gene expression in T-cells. Genes negatively associated with TL were enriched for pathways related to translation and nonsense-med

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