rs10230784 - ZKSCAN5
Magnitude 2.2 · 1 study on file
Reported associations
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A scalable variational inference approach for increased mixed-model association power - Unknown journal (n.d.) · Unknown authors · PubMed 39789286
ABSTRACT: The rapid growth of modern biobanks is creating new opportunities for large-scale genome-wide association studies (GWASs) and the analysis of complex traits. However, performing GWASs on millions of samples often leads to trade-offs between computational efficiency and statistical power, reducing the benefits of large-scale data collection efforts. We developed Quickdraws, a method that increases association power in quantitative and binary traits without sacrificing computational efficiency, leveraging a spike-and-slab prior on variant effects, stochastic variational inference and graphics processing unit acceleration. We applied Quickdraws to 79 quantitative and 50 binary traits in 405,088 UK Biobank samples, identifying 4.97% and 3.25% more associations than REGENIE and 22.71%
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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high-purine foods and beverages Moderate
Dietary purines are metabolized to uric acid; limiting them can reduce serum urate levels.
limit red meat, organ meats, shellfish, high-fructose drinks, and alcohol
Lifestyle
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adequate hydration Moderate
Increased fluid intake boosts urine output and reduces serum urate concentration.
drink at least 2-3 liters of water daily, more if exercising or in hot climates
Screening
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serum urate level Moderate
ZKSCAN5 rs10230784 A allele increases serum urate, a risk factor for gout and cardiovascular disease.
baseline serum urate check; repeat annually if elevated or at higher risk for gout