rs10227393 - RPL7P59 - DPY19L4P2

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption - Unknown journal (n.d.) · Unknown authors · PubMed 25288136

  [INTRO] Coffee, a major dietary source of caffeine, is amongst the most widely consumed beverages in the world and has received considerable attention regarding health risks and benefits. We conducted a genome-wide(GW) meta-analysis of predominately regular-type coffee consumption (cups/day) among up to 91,462 coffee consumers of European ancestry with top single-nucleotide polymorphisms (SNPs) followed-up in ~30,062 and 7,964, coffee consumers of European and African American ancestry, respectively. Studies from both stages were combined in a trans-ethnic meta-analysis. Confirmed loci were examined for putative functional and biological relevance. Eight loci, including six novel loci, met GW-significance (log10Bayes-factor>5.64) with per allele effect sizes of 0.03-0.14 cups/day. Six are

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