rs10225279 - TWIST1
Magnitude 2.2 · 2 studies on file
Reported associations
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A saturated map of common genetic variants associated with human height - Unknown journal (n.d.) · Unknown authors · PubMed 36224396
ABSTRACT: Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes. Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of increased density are enriched for biologically relevant genes. In out-of-sample estimation
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Genetic prediction of male pattern baldness - Unknown journal (n.d.) · Unknown authors · PubMed 28196072
ABSTRACT: Male pattern baldness can have substantial psychosocial effects, and it has been phenotypically linked to adverse health outcomes such as prostate cancer and cardiovascular disease. We explored the genetic architecture of the trait using data from over 52,000 male participants of UK Biobank, aged 40-69 years. We identified over 250 independent genetic loci associated with severe hair loss (P<5x10-8). By splitting the cohort into a discovery sample of 40,000 and target sample of 12,000, we developed a prediction algorithm based entirely on common genetic variants that discriminated (AUC = 0.78, sensitivity = 0.74, specificity = 0.69, PPV = 59%, NPV = 82%) those with no hair loss from those with severe hair loss. The results of this study might help identify those at greatest ris
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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male-pattern baldness management options Moderate
Genetic variant rs10225279-T in TWIST1 is associated with increased male-pattern baldness risk
If hair loss occurs, consult dermatologist to discuss minoxidil, finasteride, or hair transplantation
Screening
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hair loss progression Moderate
Early detection of male-pattern baldness allows for timely intervention if genetic predisposition becomes clinically apparent
Photograph hairline and assess hair density semi-annually or when changes are noticed