rs10224770 - MNX1
Magnitude 4.5 · 1 study on file
Reported associations
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A pilot genome‐wide association study meta‐analysis of gastroparesis - Unknown journal (n.d.) · Unknown authors · PubMed 37688361
ABSTRACT: Abstract Background Gastroparesis (GP) is characterized by delayed gastric emptying in the absence of mechanical obstruction. Objective Genetic predisposition may play a role; however, investigation at the genome‐wide level has not been performed. Methods We carried out a genome‐wide association study (GWAS) meta‐analysis on (i) 478 GP patients from the National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium (GpCRC) compared to 9931 population‐based controls from the University of Michigan Health and Retirement Study; and (ii) 402 GP cases compared to 48,340 non‐gastroparesis controls from the Michigan Genomics Initiative. Associations for 5,811,784 high‐quality SNPs were tested on a total of 880 GP patients and 58,2
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Gastroparesis risk with MNX1 variant Moderate
MNX1 rs10224770 A allele associates with 1.7x increased gastroparesis risk in individuals with diabetes
If diabetic, discuss symptoms (nausea, early satiety, bloating, vomiting) and gastric motility testing options