rs10220751 - SEMA6D

Magnitude 2.2 · 1 study on file

Reported associations

• Multitrait genome association analysis identifies new susceptibility genes for human anthropometric variation in the GCAT cohort - Unknown journal (n.d.) · Unknown authors · PubMed 30166351

  ABSTRACT: Background Heritability estimates have revealed an important contribution of SNP variants for most common traits; however, SNP analysis by single-trait genome-wide association studies (GWAS) has failed to uncover their impact. In this study, we applied a multitrait GWAS approach to discover additional factor of the missing heritability of human anthropometric variation. Methods We analysed 205 traits, including diseases identified at baseline in the GCAT cohort (Genomes For Life- Cohort study of the Genomes of Catalonia) (n=4988), a Mediterranean adult population-based cohort study from the south of Europe. We estimated SNP heritability contribution and single-trait GWAS for all traits from 15 million SNP variants. Then, we applied a multitrait-related approach to study genome-

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