Expressive

rs10220464 - TDRD9

Magnitude 2.2 · 1 study on file

Reported associations

  • Multi-omic association study identifies DNA methylation-mediated genotype and smoking exposure effects on lung function in children living in urban settings - Unknown journal (n.d.) · Unknown authors · PubMed 36638096

    ABSTRACT: Impaired lung function in early life is associated with the subsequent development of chronic respiratory disease. Most genetic associations with lung function have been identified in adults of European descent and therefore may not represent those most relevant to pediatric populations and populations of different ancestries. In this study, we performed genome-wide association analyses of lung function in a multiethnic cohort of children (n = 1,035) living in low-income urban neighborhoods. We identified one novel locus at the TDRD9 gene in chromosome 14q32.33 associated with percent predicted forced expiratory volume in one second (FEV1) (p = 2.4x10-9; βz = -0.31, 95% CI = -0.41- -0.21). Mendelian randomization and mediation analyses revealed that this genetic effect on FEV1 w

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • rs10220464 variant and lung health monitoring plan Moderate

    This variant significantly affects childhood lung function development; clinical oversight and personalized prevention strategies may reduce respiratory disease risk

Lifestyle

  • secondhand tobacco smoke exposure Moderate

    Environmental tobacco smoke exposure is associated with increased DNA methylation at cg03306306 in airway epithelial cells, which mediates the genetic effect on lung function

    Maintain smoke-free home and vehicle; encourage caregiver smoking cessation

Screening

  • lung function (spirometry/FEV1) Moderate

    The rs10220464 risk allele is associated with lower FEV1% predicted in children; baseline assessment enables early detection of impaired lung development

    Establish baseline spirometry in childhood; repeat every 2-3 years per pediatrician recommendation