rs10218792 - KIF26B
Magnitude 2.2 · 1 study on file
Reported associations
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Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 30664745
ABSTRACT: Osteoarthritis is the most common musculoskeletal disease and the leading cause of disability globally. Here, we perform a genome-wide association study for osteoarthritis (77,052 cases and 378,169 controls), analysing 4 phenotypes: knee osteoarthritis, hip osteoarthritis, knee and/or hip osteoarthritis, and any osteoarthritis. We discover 64 signals, 52 of them novel, more than doubling the number of established disease loci. Six signals fine map to a single variant. We identify putative effector genes by integrating eQTL colocalization, fine-mapping, human rare disease, animal model, and osteoarthritis tissue expression data. We find enrichment for genes underlying monogenic forms of bone development diseases, and for the collagen formation and extracellular matrix organisation
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Exercise
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Joint-protective exercise program Moderate
Regular activity supports cartilage integrity and joint function; particularly important given genetic predisposition to osteoarthritis from this variant
150 minutes moderate-intensity aerobic weekly plus resistance 2x/week
Lifestyle
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Maintain healthy body weight Moderate
Mendelian randomization in this GWAS indicates higher BMI causally increases osteoarthritis risk; rs10218792-G is associated with elevated OA susceptibility
Target BMI 18.5-24.9 kg/m2 or consult physician for personalized goal
Screening
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Early osteoarthritis screening Moderate
rs10218792-G increases osteoarthritis risk; earlier detection enables timely intervention before advanced joint changes
Discuss baseline joint imaging or functional assessment timeline with physician in 40s-50s