rs1021769 - KRT18P16 - LINC01170

Magnitude 2.2 · 1 study on file

Reported associations

• Genetic susceptibility to accelerated cognitive decline in the US Health and Retirement Study. - Neurobiology of aging (2014) · Zhang C, Pierce BL · PubMed 24468470

  Age-related cognitive decline is a major public health concern facing a large segment of the US population. To identify genetic risk factors related to cognitive decline, we used nationally representative longitudinal data from the US Health and Retirement Study to conduct genome-wide association studies with 5765 participants of European ancestry, and 890 participants of African ancestry. Mixed effects models were used to derive cognitive decline phenotypes from data on repeated cognitive assessments and to perform single nucleotide polymorphism-based heritability estimation. We found 2 independent associations among European-Americans in the 19q13.32 region: rs769449 (APOE intron; p = 3.1 × 10(-20)) and rs115881343 (TOMM40 intron; p = 6.6 × 10(-11)). rs769449 was also associated with c

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