rs10213376 - ARHGAP10
Magnitude 2.2 · 1 study on file
Reported associations
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Cross-ancestry genome-wide analysis of atrial fibrillation unveils disease biology and enables cardioembolic risk prediction - Unknown journal (n.d.) · Unknown authors · PubMed 36653681
ABSTRACT: Atrial fibrillation (AF) is a common cardiac arrhythmia resulting in increased risk of stroke. Despite highly heritable etiology, our understanding of the genetic architecture of AF remains incomplete. Here we performed a genome-wide association study in the Japanese population comprising 9,826 cases among 150,272 individuals and identified East Asian-specific rare variants associated with AF. A cross-ancestry meta-analysis of >1 million individuals, including 77,690 cases, identified 35 new susceptibility loci. Transcriptome-wide association analysis identified IL6R as a putative causal gene, suggesting the involvement of immune responses. Integrative analysis with ChIP-seq data and functional assessment using human induced pluripotent stem cell-derived cardiomyocytes demonstrat
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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baseline electrocardiogram and atrial fibrillation screening Moderate
Genetic association with atrial fibrillation risk identified in GWAS (p=5e-9, n=150,272).
Obtain baseline ECG if not recently done; discuss periodic rhythm assessment with physician.