rs10213084 - SLC10A7 - RNU1-44P

Magnitude 2.0 · 1 study on file

Reported associations

• Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders - Unknown journal (n.d.) · Unknown authors · PubMed 23583979

  ABSTRACT: Elevated resting heart rate is associated with greater risk of cardiovascular disease and mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 individuals, we identified 14 new loci associated with heart rate and confirmed associations with all 7 previously established loci. Experimental downregulation of gene expression in Drosophila melanogaster and Danio rerio identified 20 genes at 11 loci that are relevant for heart rate regulation and highlight a role for genes involved in signal transmission, embryonic cardiac development and the pathophysiology of dilated cardiomyopathy, congenital heart failure and/or sudden cardiac death. In addition, genetic susceptibility to increased heart rate is associated with altered cardiac conduction and red

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