rs10211615 - INHBB - LINC01101

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide association analyses of breast cancer in women of African ancestry identify new susceptibility loci and improve risk prediction - Unknown journal (n.d.) · Unknown authors · PubMed 38741014

  ABSTRACT: We performed genome-wide association studies (GWAS) of breast cancer including 18,034 cases and 22,104 controls of African ancestry. Genetic variants at 12 loci were associated with breast cancer risk at P <5×10-8, including associations of a low-frequency missense variant rs61751053 in ARHGEF38 with overall breast cancer (odds ratio [OR] =1.48) and a common variant rs76664032 at 2q14.2 with triple-negative breast cancer (TNBC) (OR =1.30). Approximately 15.4% of TNBC cases carried six risk alleles in three GWAS-identified TNBC risk variants, with an OR of 4.21 (95% confidence interval [CI]: 2.66, 7.03) compared with those carrying <2 risk alleles. A polygenic risk score (PRS) showed an AUC of 0.60 for the prediction of breast cancer risk, which outperformed PRSs derived using da

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