rs10211 - CYP3A7-CYP3A51P, CYP3A7

Magnitude 2.2 · 1 study on file

Reported associations

• Metagenomic and metabolomic remodeling in nonagenarians and centenarians and its association with genetic and socioeconomic factors. - Nature aging (2023) · Xu Q, Wu C, Zhu Q, Gao R, Lu J, Valles-Colomer M, Zhu J, Yin F, Huang L, Ding L, Zhang X, Zhang Y, Xiong X, Bi M, Chen X, Zhu Y, Liu L, Liu Y, Chen Y, Fan J, Sun Y, Wang J, Cao Z, Fan C, Ehrlich SD, Segata N, Qin N, Qin H · PubMed 37118062

  A better understanding of the biological and environmental variables that contribute to exceptional longevity has the potential to inform the treatment of geriatric diseases and help achieve healthy aging. Here, we compared the gut microbiome and blood metabolome of extremely long-lived individuals (94-105 years old) to that of their children (50-79 years old) in 116 Han Chinese families. We found extensive metagenomic and metabolomic remodeling in advanced age and observed a generational divergence in the correlations with socioeconomic factors. An analysis of quantitative trait loci revealed that genetic associations with metagenomic and metabolomic features were largely generation-specific, but we also found 131 plasma metabolic quantitative trait loci associations that were cross-gener

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