Expressive

rs10204976 - CSRNP3 - GALNT3

Magnitude 2.2 · 1 study on file

Reported associations

  • A cross-population atlas of genetic associations for 220 human phenotypes. - Nature genetics (2021) · Sakaue S, Kanai M, Tanigawa Y, Karjalainen J, Kurki M, Koshiba S, Narita A, Konuma T, Yamamoto K, Akiyama M, Ishigaki K, Suzuki A, Suzuki K, Obara W, Yamaji K, Takahashi K, Asai S, Takahashi Y, Suzuki T, Shinozaki N, Yamaguchi H, Minami S, Murayama S, Yoshimori K, Nagayama S, Obata D, Higashiyama M, Masumoto A, Koretsune Y, Ito K, Terao C, Yamauchi T, Komuro I, Kadowaki T, Tamiya G, Yamamoto M, Nakamura Y, Kubo M, Murakami Y, Yamamoto K, Kamatani Y, Palotie A, Rivas MA, Daly MJ, Matsuda K, Okada Y · PubMed 34594039

    Current genome-wide association studies do not yet capture sufficient diversity in populations and scope of phenotypes. To expand an atlas of genetic associations in non-European populations, we conducted 220 deep-phenotype genome-wide association studies (diseases, biomarkers and medication usage) in BioBank Japan (n = 179,000), by incorporating past medical history and text-mining of electronic medical records. Meta-analyses with the UK Biobank and FinnGen (n = 628,000) identified ~5,000 new loci, which improved the resolution of the genomic map of human traits. This atlas elucidated the landscape of pleiotropy as represented by the major histocompatibility complex locus, where we conducted HLA fine-mapping. Finally, we performed statistical decomposition of matrices of phenome-wid

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • adequate calcium intake Moderate

    Sufficient dietary calcium is required for bone mineral deposition and maintenance in the presence of genetic predisposition.

    Maintain daily calcium intake of 1000-1200 mg from dietary sources; assess dietary adequacy and supplement if needed.

Discuss with your doctor

  • personalized osteoporosis prevention strategy Moderate

    Genetic predisposition to osteoporosis warrants discussion of modifiable risk factors and whether pharmacotherapy is indicated.

Exercise

  • weight-bearing exercise Moderate

    Mechanical loading from weight-bearing activity stimulates osteoblasts and maintains bone mineral density.

    150+ minutes per week of weight-bearing or resistance exercise, or equivalent daily activity.

Screening

  • bone density screening (DEXA) Moderate

    Genetic variant associated with increased osteoporosis risk; periodic DEXA screening enables early detection of bone loss.

    Consider DEXA screening starting at age 50, or younger if additional risk factors present; repeat every 1-2 years.

Supplements

  • vitamin D supplementation Moderate

    Vitamin D is required for intestinal calcium absorption; deficiency increases osteoporosis and fracture risk.

    Supplement to achieve 25-hydroxyvitamin D level of 30-50 ng/mL; typical maintenance dose 1000-2000 IU daily.