rs10200566 - ADCY3

Magnitude 2.0 · 1 study on file

Reported associations

• Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank - Science advances (2020) · Wang H, Zhang F, Zeng J, Wu Y, Kemper KE, Xue A, Zhang M, Powell JE, Goddard ME, Wray NR, Visscher PM, McRae AF, Yang J · PubMed 31453325

  ABSTRACT: We show that genotype-by-environment interaction can be inferred from an analysis without environmental data in a large sample. Genotype-by-environment interaction (GEI) is a fundamental component in understanding complex trait variation. However, it remains challenging to identify genetic variants with GEI effects in humans largely because of the small effect sizes and the difficulty of monitoring environmental fluctuations. Here, we demonstrate that GEI can be inferred from genetic variants associated with phenotypic variability in a large sample without the need of measuring environmental factors. We performed a genome-wide variance quantitative trait locus (vQTL) analysis of ~5.6 million variants on 348,501 unrelated individuals of European ancestry for 13 quantitative traits

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