rs10200225 - MIR4435-2HG, ACOXL

Magnitude 2.0 · 1 study on file

Reported associations

• Genome-wide association study identifies several loci for HEV seropositivity - iScience (2023) · Smatti MK, Al-Sarraj YA, Albagha O, Yassine HM · PubMed 37664632

  ABSTRACT: Summary Hepatitis E viral (HEV) infection imposes a heavy global health burden. The variability in the prevalence of serological markers of HEV infection between different ethnic groups proposes a host genetic influence. Here, we report genetic polymorphisms associated with anti-HEV antibody positivity and level using binary- and quantitative-trait genome-wide association studies (GWAS) on a population from Qatar (n = 5829). We identified a region in 12p11.1 (lead SNP: rs559856097, allele: A, p = 2.3 × 10−10) significantly associated with anti-HEV antibodies level. This intergenic variant is located near SNORD112, a small nucleolar RNA (snoRNA). Additional gene-set and pathway enrichment analyses highlighted a strong correlation with anti-viral response-related pathways, i

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