Expressive

rs10198459 - PPIAP67 - LINC01117

Magnitude 2.2 · 1 study on file

Reported associations

  • Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels - Unknown journal (n.d.) · Unknown authors · PubMed 31578528

    ABSTRACT: Elevated serum urate levels cause gout and correlate with cardio-metabolic diseases via poorly understood mechanisms. We performed a trans-ethnic genome-wide association study of serum urate among 457,690 individuals, identifying 183 loci (147 novel) that improve prediction of gout in an independent cohort of 334,880 individuals. Serum urate showed significant genetic correlations with many cardio-metabolic traits, with genetic causality analyses supporting a substantial role for pleiotropy. Enrichment analysis, fine-mapping of urate-associated loci, and co-localization with gene expression in 47 tissues implicated kidney and liver as main target organs and prioritized potentially causal genes and variants, including the transcriptional master regulators in liver and kidney, HNF1

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • limit high-purine seafood Moderate

    Shellfish and fish are purine-rich; reducing purine intake lowers uric acid production

    avoid anchovies, sardines, shellfish; limit other seafood to 2-3 servings per week

  • limit red meat and organ meats Moderate

    This SNP increases serum urate; dietary purine reduction helps prevent hyperuricemia and gout

    limit red meat to 2 servings per week; avoid organ meats

Lifestyle

  • adequate daily fluid intake Moderate

    Hydration reduces urine urate concentration and crystal formation risk

    drink 2-3 liters of water daily

  • limit alcohol, especially beer Moderate

    Alcohol impairs uric acid excretion and increases production; limiting intake reduces urate levels

    limit alcohol to 1-2 drinks per week; minimize beer consumption

  • maintain healthy weight Moderate

    Obesity increases uric acid production; weight management reduces urate levels and gout risk

    target BMI below 25; aim for 5-10% weight loss if overweight

Screening

  • serum urate level screening and gout risk assessment High

    This SNP is associated with elevated serum urate across multiple large cohorts; baseline screening identifies hyperuricemia

    check serum urate level; assess for gout symptoms; repeat urate testing annually