Expressive

rs10198275 - ADCY3

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation - Unknown journal (n.d.) · Unknown authors · PubMed 27841878

    ABSTRACT: Longitudinal electronic health records on 99,785 Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort individuals provided 1,342,814 systolic and diastolic blood pressure measurements for a genome-wide association study on long-term average systolic, diastolic, and pulse pressure. We identified 39 novel among 75 significant loci (P≤5×10−8), most replicating in the combined International Consortium for Blood Pressure (ICBP, n=69,396) and UK Biobank (UKB, n=152,081) studies. Combining GERA with ICBP yielded 36 additional novel loci, most replicating in UKB. Combining all three studies (n=321,262) yielded 241 additional genome-wide significant loci, although for these no replication sample was available. All associated loci explained 2.9%/2.5%/3.1% of systolic/

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • limit dietary sodium intake Moderate

    Sodium reduction helps manage blood pressure; relevant for carriers of rs10198275 A allele with genetic predisposition to elevated BP

    target less than 2,300 mg sodium per day

Discuss with your doctor

  • personalized blood pressure management strategy Moderate

    Genetic predisposition to elevated blood pressure warrants clinical discussion of screening and management approaches

Exercise

  • regular aerobic exercise for blood pressure management Moderate

    Aerobic exercise reduces blood pressure; relevant for carriers of rs10198275 A allele with genetic predisposition to elevated BP

    150 minutes per week moderate-intensity aerobic activity

Screening

  • blood pressure screening and monitoring Moderate

    rs10198275 A allele associated with elevated systolic and diastolic blood pressure in large GWAS study

    establish baseline BP; monitor periodically or annually