Expressive

rs10197246 - FLACC1, CASP8

Magnitude 2.2 · 2 studies on file

Reported associations

  • Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449

    ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp

  • New role of fat-free mass in cancer risk linked with genetic predisposition - Unknown journal (n.d.) · Unknown authors · PubMed 38538606

    ABSTRACT: Cancer risk is associated with the widely debated measure body mass index (BMI). Fat mass and fat-free mass measurements from bioelectrical impedance may further clarify this association. The UK Biobank is a rare resource in which bioelectrical impedance and BMI data was collected on ~ 500,000 individuals. Using this dataset, a comprehensive analysis using regression, principal component and genome-wide genetic association, provided multiple levels of evidence that increasing whole body fat (WBFM) and fat-free mass (WBFFM) are both associated with increased post-menopausal breast cancer risk, and colorectal cancer risk in men. WBFM was inversely associated with prostate cancer. We also identified rs615029[T] and rs1485995[G] as associated in independent analyses with both PMB

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • postmenopausal breast cancer screening strategy Moderate

    Variant shows association with postmenopausal breast cancer risk, suggesting personalized screening approach may be warranted

    Discuss with physician at age 40-45 for baseline imaging and individualized screening plan

Lifestyle

  • rigorous daily sun protection practices High

    Genetic predisposition to melanoma requires comprehensive UV avoidance to mitigate cumulative photodamage and cancer risk

    Daily SPF30+ broad-spectrum sunscreen, UPF-rated protective clothing, avoid sun 10am-4pm, no tanning beds

Screening

  • skin cancer screening and surveillance High

    Variant associated with substantially increased melanoma risk through altered CASP8 expression affecting apoptotic pathways in skin

    Annual full-body skin examination by dermatologist; monthly self-examination starting at age 25-30