rs10197122 - HDAC4

Magnitude 2.2 · 1 study on file

Reported associations

• Genetically Determined Serum Calcium Levels and Markers of Ventricular Repolarization - Unknown journal (n.d.) · Unknown authors · PubMed 33887147

  ABSTRACT: Supplemental Digital Content is available in the text. Background: ECG markers of ventricular depolarization and repolarization are associated with an increased risk of arrhythmia and sudden cardiac death. Our prior work indicated lower serum calcium concentrations are associated with longer QT and JT intervals in the general population. Here, we investigate whether serum calcium is a causal risk factor for changes in ECG measures using Mendelian randomization (MR). Methods: Independent lead variants from a newly performed genome-wide association study for serum calcium in >300 000 European-ancestry participants from UK Biobank were used as instrumental variables. Two-sample MR analyses were performed to approximate the causal effect of serum calcium on QT, JT, and QRS interval

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