rs1019689682 - PIM3 - IL17REL

Magnitude 2.2 · 1 study on file

Reported associations

• Inflammatory and infectious upper respiratory diseases associate with 41 genomic loci and type 2 inflammation - Unknown journal (n.d.) · Unknown authors · PubMed 36653354

  ABSTRACT: Inflammatory and infectious upper respiratory diseases (ICD-10: J30-J39), such as diseases of the sinonasal tract, pharynx and larynx, are growing health problems yet their genomic similarity is not known. We analyze genome-wide association to eight upper respiratory diseases (61,195 cases) among 260,405 FinnGen participants, meta-analyzing diseases in four groups based on an underlying genetic correlation structure. Aiming to understand which genetic loci contribute to susceptibility to upper respiratory diseases in general and its subtypes, we detect 41 independent genome-wide significant loci, distinguishing impact on sinonasal or pharyngeal diseases, or both. Fine-mapping implicated non-synonymous variants in nine genes, including three linked to immune-related diseases. Phen

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