rs1019688035 - FTH1P21 - LINC02272
Magnitude 4.5 · 1 study on file
Reported associations
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Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449
ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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Outdoor time for myopia prevention Moderate
Outdoor light exposure reduces myopia progression risk and is beneficial for at-risk populations
Aim for 1-2 hours daily of outdoor time in natural daylight
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Reduce prolonged near work and visual strain Moderate
Intense near work increases myopia progression risk; limiting screen time and near-work duration may slow progression
Follow 20-20-20 rule: every 20 minutes, look 20 feet away for 20 seconds; avoid continuous near work over 2 hours
Screening
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Progressive myopia screening and monitoring High
This SNP shows strong genetic association with progressive myopia risk in a large population study
Annual eye exams or as recommended by eye care provider; report progressive myopic changes