rs10196867 - CTNNA2

Magnitude 2.2 · 1 study on file

Reported associations

• Identification of novel risk loci with shared effects on alcoholism, heroin, and methamphetamine dependence. - Molecular psychiatry (2021) · Sun Y, Chang S, Liu Z, Zhang L, Wang F, Yue W, Sun H, Ni Z, Chang X, Zhang Y, Chen Y, Liu J, Lu L, Shi J · PubMed 31462767

  Different substance dependences have common effects on reward pathway and molecular adaptations, however little is known regarding their shared genetic factors. We aimed to identify the risk genetic variants that are shared for substance dependence (SD). First, promising genome-wide significant loci were identified from 3296 patients (521 alcoholic/1026 heroin/1749 methamphetamine) vs 2859 healthy controls and independently replicated using 1954 patients vs 1904 controls. Second, the functional effects of promising variants on gene expression, addiction characteristics, brain structure (gray and white matter), and addiction behaviors in addiction animal models (chronic administration and self-administration) were assessed. In addition, we assessed the genetic correlation among the three SD

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