rs10196794 - ATG16L1
Magnitude 2.8 · 1 study on file
Reported associations
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Regulatory Variants on the Leukocyte Immunoglobulin-Like Receptor Gene Cluster are Associated with Crohn's Disease and Interact with Regulatory Variants for TAP2. - Journal of Crohn's & colitis (2024) · Kim K, Oh SJ, Lee J, Kwon A, Yu CY, Kim S, Choi CH, Kang SB, Kim TO, Park DI, Lee CK · PubMed 37523193
Crohn's disease [CD] has a complex polygenic aetiology with high heritability. There is ongoing effort to identify novel variants associated with susceptibility to CD through a genome-wide association study [GWAS] in large Korean populations. Genome-wide variant data from 902 Korean patients with CD and 72 179 controls were used to assess the genetic associations in a meta-analysis with previous Korean GWAS results from 1621 patients with CD and 4419 controls. Epistatic interactions between CD-risk variants of interest were tested using a multivariate logistic regression model with an interaction term. We identified two novel genetic associations with the risk of CD near ZBTB38 and within the leukocyte immunoglobulin-like receptor [LILR] gene cluster [p < 5 × 10-8], with highly co
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Crohn's disease genetic risk with provider High
ATG16L1 rs10196794-A allele increases Crohn's disease risk 29% per copy; discussion with provider enables informed screening and management.
Screening
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Inflammatory bowel disease symptoms High
ATG16L1 is critical for autophagy and bacterial handling in intestinal immune cells; increased Crohn's risk warrants heightened symptom awareness.
Monitor for and report abdominal pain, diarrhea, weight loss, or bloody stools to provider