rs10196396 - LAPTM4A-DT - RPS16P2
Magnitude 2.2 · 1 study on file
Reported associations
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Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449
ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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limit dietary sodium intake Moderate
High sodium increases urinary calcium, key component in kidney stones
Target <2300mg sodium daily; consult urologist for personalized limits
Lifestyle
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increase daily water intake for kidney stone prevention Moderate
High urine volume reduces concentration of stone-forming minerals
Aim for 2.5-3L urine output daily; increase fluid intake as needed
Screening
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baseline kidney imaging for stone assessment Moderate
Variant strongly associated with kidney stone formation
Discuss baseline ultrasound or CT abdomen with physician