rs10192403 - ACYP2
Magnitude 2.8 · 1 study on file
Reported associations
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Genetic relationships between high blood eosinophil count, asthma susceptibility, and asthma severity. - The Journal of asthma : official journal of the Association for the Care of Asthma (2024) · Li H, Li X · PubMed 37560908
Genetic relationships between blood eosinophil count (BEC), asthma susceptibility, and severity are unclear. We sought to identify the genetic difference between type 2 (T2) and nontype 2 (non-T2) asthma (defined by BEC) and investigate genetic relationships between high BEC, asthma susceptibility, and severity. Genome-wide association studies (GWASs) were performed for T2 ( = 9,064; BEC ≥ 300 cells/μL) versus non-T2 asthma ( = 14,379; BEC < 150 cells/μL) and asthma susceptibility (37,227 asthmatics vs. 124,132 nonasthma controls) in the UK Biobank and asthma severity (moderate-to-severe asthma [ = 2,153] vs. mild asthma [ = 5165]) in the All of Us Research Program (AoURP). Genetic causality between BEC, asthma susceptibility, and severity were dissected using Mendelian randomi
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Genetic predisposition to severe asthma Moderate
T allele at rs10192403 associates with elevated moderate-to-severe asthma risk; discussion can guide optimal control strategy
Share this genetic finding with your primary care physician or pulmonologist
Screening
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Asthma control and severity assessment Moderate
Variant rs10192403 associates with 1.23-fold increased odds of moderate-to-severe versus mild asthma; regular monitoring helps detect worsening disease early
Assess asthma control quarterly or when symptoms worsen